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Prevalence of Infectious Diseases Among Adopted Children From Ethiopia

Sunday, October 21, 2012: 4:00 PM
Grand Salon D21/D24 (Hilton Riverside)
Senait Adebo, Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA

Purpose: In 2010, 2511 children were adopted from Ethiopia by U.S. families, representing 23% of all countries adoption. However, little is known about the infectious disease prevalence among these children. The objective of this study is to describe the infectious diseases prevalence in this population and associated factors.

Methods: A retrospective chart review of 255 children adopted from Ethiopia and evaluated from 2006-2011 at the international adoption clinic was done. One reviewer reviewed all infectious disease screens in each record. Initial and subsequent visit records were reviewed.

Results: The mean age of the study participants at medical evaluation was 1.4 years (range: 1 month to14.9 years); 58 % were girls.  Ninety-one percent lived in an orphanage setting before adoption and stayed for 1 month to 9 years in institutions.

Of the 142 children evaluated for tuberculosis, either by tuberculin skin tests or Quantiferon Gold, forty four children had evidence of latent tuberculosis (31 %). None of these children had chest x-ray findings consistent with tuberculosis, and all were treated for latent tuberculosis.  Six of 133 children (3 %) had detectable hepatitis B surface antigen (HBsAg).

Of the 44 children tested for malaria 7 (16 %) had infection with a Plasmodium species. Two of these children were diagnosed by a positive blood smear (both children had both P vivax and  P. falciparum), and five by a PCR test two were positive for P. falciparum and three had P vivax. No child had infection with hepatitis C, HIV or syphilis. 96 children of 217 tested for intestinal pathogens (44 %) had 1 or more pathogens identified. G lamblia antigen was detected in 75 (19%) of 193 children screened. 81 Children had stool microscopy positive for 1 more parasite G. lamblia  and Blastocystis hominis being the most common ones.

Conclusion: The frequency of latent tuberculosis and asymptomatic malaria are higher in children adopted from Ethiopia than those reported in children adopted from other countries.