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The Response of Toll-Like Receptors to Glutamine In Neonatal Rat Intestine

Friday, October 19, 2012
Room R02-R05 (Morial Convention Center)
Abdulbaki Karaoglu1, Turan Tunc1, Gokhan Aydemir2, Ferhat Cekmez3, Mustafa Kul2, Secil Aydinoz2, Vural Kesik1, Taner Ozgurtas1 and Umit Sarici1, (1)Gulhane Military Medical Academy, Ankara, Turkey, (2)Pediatrics, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey, (3)Neonatology, GATA Medical Faculty, Ankara, Turkey

Purpose: There are several barrier systems in the newborn gastrointestinal tract and one of the most important among these are the Toll-like receptors. The aim of this study was to examine the effect of glutamine on Toll-like receptors 2, 4, and 9 levels in the newborn gut.   

Methods: Rats were randomly assigned to three experimental groups. Group I (control at day 0) (n = 9): group II (control at day 10) (n = 9): oral distilled water, group III (study group) (n = 9): oral glutamine (200 mg/kg/day). After 10 days, the ileojejunal segment was removed for biochemical analyses of toll-like receptors 2, 4 and 9.

 Results: There was a significant difference between groups for the levels of Toll-like receptors. The level of Toll-like receptor 9 was higher in Group I than Group II and in Group III than Group II. There was no statistically significant difference between Group I and Group III in terms of Toll-like receptor 9 levels. There were no statistically significant differences between groups for the levels of Toll-like receptor 2 and 4.

 Conclusion: Glutamine administration, by increasing the level of Toll-like receptor 9, may prevent the increase in the level of Toll-like receptor 4 in newborn rat intestine. Thus, it may play a protective role in the intestine and reduce the susceptibility to necrotizing enterocolitis (NEC), which is associated with the intensity of Toll-like receptor 4 expression.